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pentobarbital will reduce the level or effect of mestranol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will lower the level or effect of mavacamten by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.Animal info. Phenobarbital sodium is carcinogenic in mice and rats after lifetim